Effect of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Polypeptide on Mouse Preantral Follicle Development in Vitro

Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide activate hyperpolarization-activated cationic current and depolarize thalamocortical neurons in vitro.

Ascending pathways mediated by monoamine neurotransmitters regulate the firing mode of thalamocortical neurons and modulate the state of brain activity. We hypothesized that specific neuropeptides might have similar actions. The effects of vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) were tested on thalamocortical neurons using whole-cell pa...

Pituitary adenylate cyclase activating polypeptide and migraine

Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headach...

Cerebrovascular Effects of Pituitary Adenylate Cyclase Activating Polypeptide and Vasoactive Intestinal Peptide in Newborn Pigs

Article history:Accepted 19 June 2007Available online 27 June 2007Pituitary adenylate cyclase-activating polypeptide (PACAP) is a cerebrovascular dilator andwas found neuroprotective in numerous in vitro and in vivo models of cerebral ischemia.However, the mechanism of its cerebrovascular action is poorly known, especially innewborns. Therefore, we tested pial arteriolar...

Inhibit Expression of Fas Ligand in Activated Adenylate Cyclase-Activating Polypeptide Vasoactive Intestinal Peptide and Pituitary

Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide inhibit dendritic growth in cultured sympathetic neurons.

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are related neuropeptides that are released by the preganglionic sympathetic axons. These peptides have previously been implicated in the regulation of sympathetic neurotransmitter metabolism and cell survival in postganglionic sympathetic neurons. In this study we consider the possibility that PA...